Competitive Binding of Some Alkyl p-Hydroxybenzoates to Human Estrogen Receptor α and β
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چکیده
منابع مشابه
Estrogen receptor beta activates the human retinoic acid receptor alpha-1 promoter in response to tamoxifen and other estrogen receptor antagonists, but not in response to estrogen.
Human estrogen receptor-alpha (hERalpha) or -beta (hERbeta) transfected into Hep G2 or COS1 cells each responded to estrogen to increase transcription from an estrogen-responsive element (ERE)-driven reporter vector with similar fold induction through a classical mechanism involving direct receptor binding to DNA. ER antagonists inhibited this estrogen induction through both hERalpha and hERbet...
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In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is the first report on the expression of estrogen receptor beta (ERbeta) in comparison with ERalpha mRNA during mouse embryogenesis. We found expression of estrogen receptor mRNA in the reproductive trac...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2000
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.120.12_1429